Studies in a variety of animal species have shown significant behavioral toxicity after administration of WR- 2721 (Bogo et al., 1985 Bogo, 1988 Landauer et al., 1987b, 1988).« lessĭetermination of the cytoprotective agent WR- 2721 (Amifostine, Ethyol) and its metabolites in human blood using monobromobimane fluorescent labeling and high-performance liquid chromatography. Diethyldithiocarbamate (DDC) and N-acetylcysteine (NAC) are othermore » compounds shown to have radioprotective properties (Milas et al., 1988 Weiss et al., 1984). B-Mercaptoethylamine (MEA, cysteamine) was for years the standard against which the effectiveness of other radioprotectors was judged, but is more toxic than WR- 2721 (Giambarresi and Jacobs, 1987). This drug is currently under clinical investigation for its potential in protecting normal tissue during radiation treatment and chemotherapy (Blumberg et al., 1982 Glover et al., 1988 Yuhas et al., 1980). One of the most effective radioprotectors is S- 2(3- aminopropylamino)ethylphosphorothioic acid, also known aas ethiofos, gammaphos, or WR- 2721 (Davidson, 1980 Giambarresi and Jacobs, 1987). Dominitz, J.A.Ī number of sulfhydryl compounds have been shown to protect against ionizing radiation. The use of topical MEA on unanesthetized animals breathing carbogen (95% O 2, 5% CO 2) appears to give an enhanced level of radioprotection over that shownmore » for anesthetized, air-breathing animals.« lessĬomparative behavioral toxicity of four sulfhydryl radioprotective compounds in mice: Wr 2721, cysteamine, diethyldithiocarbamate, and n-acetylcysteine MEA was shown to offer significant protection against acute skin damage in both buffered and unbuffered forms, but no significant protection against late contraction. No significant protection was observed with either WR- 2721 or NAC. Topical applications of MEA (beta-mercaptoethylamine or cysteamine), WR- 2721 ( S- 2-(3- aminopropylamino)-ethylphosphorothioic acid), and N-acetylcysteine (NAC) were tested for their ability to protect the normal skin of the hind legs of mice against acute and late damage from single doses of /sup 137/Cs radiation. Determination of the radioprotective effects of topical applications of MEA, WR- 2721, and N-acetylcysteine on murine skinĭOE Office of Scientific and Technical Information (OSTI.GOV)
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